Medicine: Recent submissions

Now showing items 21-40 of 4649

Abundance and taxonomic characterization of chigger mites (Acari: Trombiculidae and Walchiidae) associated with rodents in selected scrub typhus-prone areas in Southern and Western provinces of Sri Lanka

Liyanage, A.; Gunathilaka, N.; Premarathne, R.; Chandrasena, N.; Jacinavicius, F.D.C.; Silva, R.B. (University of Kelaniya, 2024)

Larval trombiculid mites (chiggers) are the vectors and reservoirs of the potentially lethal infectious disease, scrub typhus (ST) caused by Orientia tsutsugamushi. Small rodents are natural hosts of parasitic larval stage ...
Parasitological screening of vector mosquitoes and molecular biological identification of larval filarial parasites among the wildcaught Mansonia mosquito species at selected areas in the district of Gampaha, Sri Lanka, a re-emerging focus of Brugian filariasis

Gunathilaka, N.; Wimalasiri, U.; Chandrasena, N.; Dalpadadu, R. (University of Kelaniya, 2024)

Brugian filariasis, a disease caused by the Protozoan parasiteBrugia malayi has re-emerged in Sri Lanka after nearly four decades of quiescence. The Brugia malayi that prevailed in Sri Lanka in the past was the nocturnal ...
Pilot study for non-invasive diabetes detection through classification of photoplethysmography signals using convolutional neural networks

Gunathilaka, H.J.; Rajapaksha, R.; Kumarika, T.; Perera, D.; Herath, U.; Jayathilaka, C.; Liyanage, J.A.; Kalingamudali, S.R.D. (University of Kelaniya, 2024)

Diabetes is a chronic disorder affecting vascular health, often altering pulse wave characteristics. Traditional pulse wave analysis (PWA) methods face challenges such as variability and complexity of signals. This study ...
Hypertension,hyperkalaemia and metabolic acidosis and low serum renin activity: a case report on psuedohypoaldosteronism type 2 in a six-year-old child

Fernando, K.; Lankapriya, K.R.; Kumarasiri, I.M.; Wijesuriya, H.T.S.K.; Seneviratne, S.N. (College of Chemical Pathologists of Sri Lanka, 2024)

INTRODUCTION Pseudohypoaldosteronism type 2 (PHA II), also known as Gordon syndrome or familial hyperkalaemia and hypertension syndrome, is a rare cause of monogenic low renin hypertension.Its clinical profile commonly ...
Impact of acalypha indica (Kuppamenia) phytochemicals on glucose-6-phosphate dehydrogenase deficiency: two clinical case studies

Fernando, K.; Fernando, N.; Dayanath, B.K.T.P.; Williams, S.; Premawardhena, A. (College of Chemical Pathologists of Sri Lanka, 2024)

INTRODUCTION Acalypha indica, known as “kuppamenia” in Sinhala, plays a significant role in ayurvedic medicine in Sri Lanka. Despite its medicinal use, certain phytochemicals within the plant have been linked to oxidative ...
Evaluation of point-of-care testing (poct) devices for cardiac troponin i in screening patients with myocardial infarction

Fernando, K.; Jayasekara, D.; Kulasinghe, M.; Silva, P.; Harshanee, K.G.A.T.; Bandara, S.R.R.; Dayanath, B.K.T.P. (College of Chemical Pathologists of Sri Lanka, 2024)

INTRODUCTION AND OBJECTIVES Cardiac troponin I (cTnI) is a crucial biomarker for diagnosing myocardial infarction (MI). However, many remote hospitals lack access to cTnI assessment facilities. This study investigates the ...
Comparative analysis of alkaline phosphatase with two assays using different buffers; diethanolamine (dea) and 2-amino-2-methyl-1-propanol (amp): establishing correlation factors for diagnostic consistency

Jayasekara, D.; Fernando, K.; Kulasinghe, M.; Silva, P.; Madurangi, D.W.D.D.; De Silva, D.D.S.; Harshanee, K.G.A.T.; Bandara, S.R.R.; Dayanath, B.K.T.P. (College of Chemical Pathologists of Sri Lanka, 2024)

INTRODUCTION AND OBJECTIVES Alkaline phosphatase (ALP) serves as a pivotal biomarker for bone and liver diseases, employing assays utilizing either 2-amino-2-methyl-1-propanol (AMP) (IFCC recommended) or diethanolamine ...
Comparative Analysis of Albumin Measurement by Bromocresol Green Versus Capillary Zone Electrophoresis

Harshanee, T.; Jayasekara, D.; Fernando, K.; Kulasinghe, M.; Silva, P.; Bandara, S.; Dayanath, B.K.P.T. (College of Chemical Pathologists of Sri Lanka, 2024)

INTRODUCTION Quantitative assessment of albumin and globulins in serum protein electrophoresis (SPE) relies on the calculation derived from total protein measurements obtained from the biuret assay. Validation of these ...
Do doctors really know about “hs-cTnI”? A comprehensive evaluation of knowledge regarding high-sensitivity cardiac troponin I (hs-cTnI) assay among medical officers in Gampaha district

Fernando, N.; Fernando, K.; Gallage, T.; Dayanath, B.K.T.P.; De Silva, S. (College of Chemical Pathologists of Sri Lanka, 2024)

INTRODUCTION AND OBJECTIVES The high-sensitivity cardiac troponin I (hs-cTnI) assay is a crucial diagnostic marker in the triage of patients presenting with chest pain. Notably, errors in interpreting the testing method ...
A prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts

Chandrasinghe, P. (NIHR Global Health Research Unit on Global Surgery and STARSurg Collaborators) (Elsevier Ltd, 2024)

BACKGROUND Pulmonary complications are the most common cause of death after surgery. This study aimed to derive and externally validate a novel prognostic model that can be used before elective surgery to estimate the risk ...
Proteome profiling of cutaneous leishmaniasis lesions due to dermotropic Leishmania donovani in Sri Lanka

Manamperi, N.H.; Edirisinghe, N.M.; Wijesinghe, H.; Pathiraja, L.; Pathirana, N.; Wanasinghe, V.S.; De Silva, C.G.; Abeyewickreme, W.; Karunaweera, N.D. (BioMed Central, 2024)

BACKGROUND Characterization of the host response in cutaneous leishmaniasis (CL) through proteome profiling has gained limited insights into leishmaniasis research compared to that of the parasite. The primary objective ...
Patients’ right to confidentiality and sharing information with colleagues: The dilemma in managing a patient with Munchausen syndrome – A case report

Welhenage, C.U.; Premawardhena, A. (Ceylon College of Physicians, 2024)

We report the case of a young woman with a “pyrexia of unknown origin” in the background of a history involving SLE, ocular toxoplasmosis and Ig A nephropathy. The history was narrated by her with precise details but there ...
Solid pseudopapillary tumour of the pancreas: an uncommon pancreatic tumour in Sri Lanka

Tillakaratne, S.B.; Cooray, S.; Gunetilleke, B.; Siriwardana, R. (The college of surgeons of Sri Lanka, 2024)

INTRODUCTION AND OBJECTIVES Solid pseudopapillary tumour of the pancreas (PST) is a rare exocrine pancreatic tumour commonly involving the body and the tail of the pancreas. It's seen predominantly in young women. Even ...
A cadaveric study on superior hypogastric plexuses

Abeysuriya, V.; Akalanka, H.G.L.; Kumarage, S. (The College of Surgeons of Sri Lanka, 2024)

INTRODUCTION The superior hypogastric plexus (SHP) is found around the level of aortic bifurcation. It is important in surgical procedures in the pelvis. Methods Ten (5; M & 5; F) fresh intact adult human cadavers were ...
Stroke in old age

Ranawaka, U. (Ceylon College of Physicians, 2024)

Strokes are more common in old age, and with an increasingly ageing population, Sri Lanka is likely to witness a dramatic increase in older patients with stroke. Strokes are different, are more severe and lead to more ...
Predictors of response to electroconvulsive therapy in major depressive disorder: A review of research findings

Baminiwatta, A.; Menon, V. (Springer, 2024)

PURPOSE OF REVIEW In the context of the current global move towards precision medicine, considering the adverse effects, costs and efficacy limitations of electroconvulsive therapy (ECT) in major depression, this review ...
Non-invasive diagnostic approach for diabetes using pulse wave analysis and deep learning

Gunathilaka, H.; Rajapaksha, R.; Kumarika, T.; Perera, D.; Herath, U.; Jayathilaka, C.; Liyanage, J.; Kalingamudali, S. (MDPI, 2024)

The surging prevalence of diabetes globally necessitates advancements in non-invasive diagnostics, particularly for the early detection of cardiovascular anomalies associated with the condition. This study explores the ...
Retinoblastoma patients treated in Sri Lanka from 2014 to 2020: epidemiology, clinical status and correlates of lag time in seeking tertiary care services

Kugalingam, N.; De Silva, D.; Abeysekera, H.; Nanayakkara, S.; Tirimanne, S.; Chandrasekharan, V.; Jayawardana, P.L. (BioMed Central, 2024)

BACKGROUND Retinoblastoma (RB) is a tumour of children < 5 years with a incidence of 1 in 20,000. Around 20 RB cases are diagnosed yearly in Sri Lanka, a lower middle-income country with high literacy levels and healthcare ...
Unilateral basal ganglia infarction presenting as sudden onset daytime sleepiness

Mettananda, K.C.D.; De Saram, E.M.T.K.; Wickramasinghe, M.K.I.I.; Siriwardana, S.A.S.R. (Sri Lanka College of Internal Medicine, 2024)

Basal ganglia (BG) are involved in motor coordination. BG strokes usually present with problems controlling speech, movements, mood and posture leading to abulia which is a prominent feature. BG stroke presenting with ...
Comparing two different presentations of Takayasu arteritis

Kurukulasuriya, S.A.F.; Munidasa, D. (Sri Lanka College of Internal Medicine, 2024)

Reported here are two Asian patients with Takayasu arteritis (TA) with contrasting presentations and responses to treatment. The first patient was a 53-year-old man who presented with disabling abdominal pain. Imaging ...

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