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2'-Deoxy-5-ethyl-beta-4'-thiouridine inhibits replication of murine gammaherpesvirus and delays the onset of virus latency

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dc.contributor.author Barnes, A. en_US
dc.contributor.author Dyson, H. en_US
dc.contributor.author Sunil-Chandra, N.P. en_US
dc.contributor.author Collins, P. en_US
dc.contributor.author Nash, A. A. en_US
dc.date.accessioned 2014-10-29T09:18:22Z
dc.date.available 2014-10-29T09:18:22Z
dc.date.issued 1999 en_US
dc.identifier.citation Antiviral Chemistry Chemotherapy. 1999; 10(6): 2321-326 en_US
dc.identifier.issn 0956-3202 (Print) en_US
dc.identifier.issn 2040-2066 (Electronic) en_US
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/1402
dc.description Indexed in MEDLINE
dc.description.abstract The antiviral thionucleoside analogue 2'-deoxy-5-ethyl-beta-4'-thiouridine (4'-S-EtdU) was shown to be a more potent inhibitor of gammaherpesvirus infection than acyclovir. This compound inhibits replication of murine herpesvirus (MHV)-68 in the lungs of mice when given 3 days post-infection. However, as with other nucleoside analogues, it was unable to prevent the establishment of latency, despite delaying the onset of latent infection in the spleen. In contrast, virus persistence in the lung was inhibited following drug treatment, although persistence was re-established in mice when treatment was suspended after 12 days. These data suggest that 4'-S-EtdU is a highly effective inhibitor of murine gamma herpesvirus replication and as such provides a powerful tool to study the pathogenesis of this virus in vivo.
dc.publisher International Medical Press en_US
dc.subject.mesh Antiviral Agents-pharmacology
dc.subject.mesh Gammaherpesvirinae
dc.subject.mesh Gammaherpesvirinae-drug effects
dc.subject.mesh Gammaherpesvirinae-physiology
dc.subject.mesh Thiouridine
dc.subject.mesh Virus Latency-drug effects
dc.subject.mesh Virus Replication-drug effects
dc.title 2'-Deoxy-5-ethyl-beta-4'-thiouridine inhibits replication of murine gammaherpesvirus and delays the onset of virus latency en_US
dc.type Article en_US
dc.identifier.department Microbiology en_US


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