Evaluation of anti–oxidant properties of a traditional formulae (JB Kalka).
Shifra, A.S.F.; Gunasekara, G.V.M.T.D.; Kularathna, M.D.C.N.; Cooray, P.L.J.U.D.; Perera, H.M.P.; Fernando, S.H.S.; Sadungama, M.K.N.G.; Thilakarathna, B.S.D.; Kuruppuarachi, S.N.; Kuruppuarachi, S.N.; Saranya, U.; Rishad, Y.M.; Kaluthotage, S.; Kularathne, D.A.B.H.; Umayanagni, L.H.S.
Citation:
Shifra, A.S.F., Gunasekara, G.V.M.T.D., Kularathna, M.D.C.N., Cooray, P.L.J.U.D., Perera, H.M.P.,Fernando, S.H.S., Sadungama, M.K.N.G., Thilakarathna, B.S.D., Kuruppuarachi, S.N., Saranya, U., Rishad, Y.M., Kaluthotage, S., Kularathne, D.A.B.H. and Umayanagni, L.H.S. (2017). Evaluation of anti–oxidant properties of a traditional formulae (JB Kalka). Salakya Sandipani, Department of Shalya Shalakya, Gampaha Wickramarachchi Ayurveda Institute, University of Kelaniya, Sri Lanka.p 107.
Date:
2017
Abstract:
Cancer is a group of diseases involving abnormal cell growth with the potential to invade to other
parts of the body. In Ayurveda, cancer is dened in the term Arbuda, which is categorized by big,
deep seated, immovable, round, slightly painful and slowly increasing Arbuda which is caused
by penetration of increased Doshas into the body tissues and blood. In 2012, about 14.1 million
new cases of cancer were reported globally and it caused 8.2 million or 14.6% of deaths. Though
there are several advanced treatment strategies available in the management of cancer in modern
medical system, most of them cause lots of side effects. But JB Kalka is a traditional preperation
which is being successfully practiced by Kottayawatta generation in the management of cancer
without any side effects. This formula was selected to demonstrate literature review of its all
ingredients and to evaluate its anti-oxidant properties and physicochemical parameters. The JB
Kalka was prepared according to the guidelines indicated by the traditional practitioners. The
literature review of all ingredients was compiled from Ayurvedic classical texts, electronic
databases of Google scholar, PubMed and through web search. As per literature review, JB Kalka
has properties of Katu- Thiktha- Kasaya Rasa, Laghu- Theekshana Guna, Ushna Veerya and
Katu Vipaka which regulate Thridoshas by pacifying Kapha and Vata and increasing Pitta. This
study shows an anti-oxidant properties of JB kalka according to DPPH method by colour change
from purple into pale yellow. According to the quantitative test, methanolic extract of JB Kalka
exhibited highest potential for DPPH radical scavenging activity as it had the least IC50 value of
around 1.25 mg/ml. Therefore, JB Kalka is an effective medicinal preparation to be used in the
tratment of cancer as an anti-cancer drug. But further studies with large sample should be carried
out to scientically justify the effectiveness of JB Kalka in the management of cancer and to
identify an immune modulatory, cyto toxic and anti-cancer properties of JB Kalka.
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