A randomized single blind comparative trial to evaluate the efficacy of whole plant of Phyllanthus niruri Linn. crude powder with Pushyanuga Churna in the management of Rakta Pradara due to Dysfunctional Uterine Bleeding (DUB).

Abstract

According to Ayurveda, Raktapradara has been explained under Artava Vyapad. It resembles with menorrhagia explained in allopathic medicine. Dysfunctional Uterine Bleeding (DUB) is an abnormal uterine bleeding without any obvious structural or systemic pathology .Bumyamalaki (Phyllanthus niruri. Linn) has been recommended in the management of Raktapradara with rice washed water. Pushyanuga Churna was selected as positive control drug for DUB. Female patients in the age between 12-50 years who were diagnosed with Raktapradara due to DUB were included in the study. A total of 60 patients were randomly divided into group A and group B with 30 patients in each. The study aimed at evaluating the comparative effect on the amount of blood loss, duration, intermenstrual period and pain relieving property and ability to relief its associated symptoms such as Angamarda and Arati. The observed values of Hb%, BT, CT platelet count, urine and endometrial thickness before treatment was within normal ranges. Data were collected and recorded before the trial and three follow ups monthly with treatment within the trial and after one month without treatment were done. At the last follow up all investigations were again repeated to analyze if any changes were seen after the therapy. The t-test was applied to the mean of observed values before and after treatment. P. niruri. made to evaluate phyto and physico-chemical properties and anti- oxidant activity of P. niruri grown in Sri Lanka. The improvement parameters were signicant statistically (p<0.05). According to the results, 7.7±0.2% of total ash, 3.4±0.1% of water soluble ash and 0.9±0.0% of acid insoluble ash were present in the whole plant of P. niruri. Phytochemical screening reveals the presence of tannins, avonoids, steroid glycosides, coumarins, saponins and cardiac glycosides in both hot water and hot methanolic extracts of P.niruri. TLC nger print prole of the methanolic extract of P. niruri consists of 8 and 9 prominent spots at 254 nm and 366 nm respectively. These results can be used as a reference standard for quality control of P. niruri grown in Sri Lanka. The anti- oxidant activity of P. niruri powder hasP<0.05 which can be regarded as signicant.