Immunomodulatory Efficiency of Tinospora Cordifolia Against Viral Infections

Abstract

Most of the cases, viral infected patients are suffering from secondary infections. Apart from that, due to the exhausted Immune system patients more vulnerable to secondary Infections and various diseases. Dysfunction of the immune system is responsible for multiple illnesses, such as arthritis, ulcerative colitis, asthma, allergies, parasites, cancer, and infectious diseases. So, medicinal plants and their active components are becoming increasingly relevant as a source of immunomodulatory agents. T. cordifolia stem extracts or the isolated compounds of the plant exhibits amazmg immune stimulatory effects in various ways isolated compounds of T. cordifolia such as N-methyl-2-pyrrolidone and Il-hydroxymustakone, Magnoflorme and Tinocordiside shows immunomodulatory effects by enhancing Reactive Oxygen Species (ROS) generation which causes to augment the Immune response. T. cordifoüa extract exhibits a considerable effect of the immunostimulation in HW positive patients and, increases the phagocytosis and intercellular killing capacity by increasing the survival rate and polymorphonuclear leucocyte function. In addition to that, a novel (1,4)-∝-D-glucan from T. Cordifoüa activates the immune system by activatmg macrophages via of TLR6 signaling and NF-kB activation mechanism, leading to cytokine and chemokme production. Immunoductatory protem (Imp) obtained from the dry stem powder of Tinospora cordifoüa is significant for augmenting the various immunological activities in the human body. Hence, more attention should be focused on the phytochemistry and their applications of the Tinospora cordifolta for Immune enhancements as well as reduce secondary infections risks along with the viral infections.