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Changes in biochemical markers of outcomes in haemodialysis patients following a clinical pharmacy intervention.

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dc.contributor.author Kalpani, A.G.S.
dc.contributor.author Mohamed, F.
dc.contributor.author Hough, J.E.
dc.contributor.author de Silva, D.N.N.
dc.contributor.author Chandrasena, W.M.H.N.M.
dc.contributor.author Jayamanne, S.F.
dc.date.accessioned 2022-01-24T09:32:52Z
dc.date.available 2022-01-24T09:32:52Z
dc.date.issued 2021
dc.identifier.citation Journal of the Ceylon College of Physicians,2021;52(1):13. en_US
dc.identifier.issn 0379-802X
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/24403
dc.description Oral Presentation Abstract (OP 06), 54th Anniversary academic sessions of the College of Physicians. 2021, 7th – 9th October. Colombo,Sri Lanka. en
dc.description.abstract Introduction and Objectives Common complications of End-Stage Renal Disease (ESRD) include cardiovascular disease, diabetes, anaemia and mineral and bone disease. Achieving an optimum level of biochemical markers of outcomes is crucial in managing ESRD. This study was conducted to assess the changes in selected biochemical parameters following a clinical pharmacy intervention (CPI) in this population. Method A randomized controlled trial was conducted at outpatient haemodialysis units in North Central Province, Sri Lanka. Serum phosphate, serum calcium, haemoglobin, lipid profile, eGFR and 'adequacy of dialysis* (AoD) (determined by urea reduction ratio (URR); calculated based on pre-post blood urea nitrogen measurements and Kt/V measurements) were measured in patients at baseline (BL) and after one year (PI). The Intervention Group (IG), n=143 patients received comprehensive pharmaceutical care by the clinical pharmacist on four consecutive occasions at recruitment, and 2, 6 and 10 months after recruitment. While the Control Group (CG), n=140, received standard care. Results At the baseline, there was no significant difference in the biochemical markers of outcomes between the two groups and AoD was within the acceptable range. However, there was a significant improvement in the mean serum phosphate levels (IG 4.04±1.19 vs CG 5.00±1.67, p<0.0001), mean serum calcium levels (IG 8.90±1.35 vs CG 7.11±2.07, p<0.0001), and mean haemoglobin levels (IG 10.5±1.25 vs CG 9.4±1.87, p<0.0001) in the IG compared to the CG at the end of one year. However, eGFR, lipid profiles did not change significantly (p>0.05). AoD was within the acceptable range in both groups at baseline and post intervention and did not change significantly (p>0.05) Conclusions Improvement in the selected biochemical markers of outcomes resulting from CPI suggests better patient management outcomes in the ESRD population. en_US
dc.language.iso en en_US
dc.publisher Ceylon College of Physicians en_US
dc.subject HAEMODIALYSIS en_US
dc.subject BIOCHEMICAL en_US
dc.title Changes in biochemical markers of outcomes in haemodialysis patients following a clinical pharmacy intervention. en_US
dc.type Article en_US


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    Papers presented at local and international conferences by the Staff of the Faculty of Medicine

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