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A saturated map of common genetic variants associated with human height

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dc.contributor.author Vedantam, S.
dc.contributor.author Marouli, E.
dc.contributor.author Sidorenko, J.
dc.contributor.author Bartell, E.
dc.contributor.author Sakaue, S.
dc.contributor.author Graff, M.
dc.contributor.author Eliasen, A.U.
dc.contributor.author Jiang, Y.
dc.contributor.author Raghavan, S.
dc.contributor.author Miao, J.
dc.contributor.author Arias, J.D.
dc.contributor.author Graham, S.E.
dc.contributor.author Mukamel, R.E.
dc.contributor.author Spracklen, C.N.
dc.contributor.author Yin, X.
dc.contributor.author Chen, S.H.
dc.contributor.author Ferreira, T.
dc.contributor.author Highland, H.H.
dc.contributor.author Ji, Y.
dc.contributor.author Karaderi. T,
dc.contributor.author Lin, K.
dc.contributor.author Lüll, K.
dc.contributor.author Malden, D.E.
dc.contributor.author Medina-Gomez, C.
dc.contributor.author Machado, M.
dc.contributor.author Moore, A.
dc.contributor.author Rüeger, S.
dc.contributor.author Sim. X,
dc.contributor.author Vrieze, S.
dc.contributor.author Ahluwalia, T.S.
dc.contributor.author Akiyama, M.
dc.contributor.author Allison, M.A.
dc.contributor.author Alvarez, M.
dc.contributor.author Andersen, M.K.
dc.contributor.author Ani, A.
dc.contributor.author Appadurai, V.
dc.contributor.author Arbeeva, L.
dc.contributor.author Bhaskar, S.
dc.contributor.author Bielak, L.F.
dc.contributor.author Bollepalli, S.
dc.contributor.author Bonnycastle, L.L.
dc.contributor.author Bork-Jensen, J.
dc.contributor.author Bradfield, J.P.
dc.contributor.author Bradford, Y.
dc.contributor.author Braund, P.S.
dc.contributor.author Brody, J.A.
dc.contributor.author Burgdorf, K.S.
dc.contributor.author Cade, B.E.
dc.contributor.author Cai, H.
dc.contributor.author Cai, Q.
dc.contributor.author Campbell, A.
dc.contributor.author Cañadas-Garre, M.
dc.contributor.author Catamo, E.
dc.contributor.author Chai, J.F.
dc.contributor.author Chai, X.
dc.contributor.author Chang, L.C.
dc.contributor.author Chen, C.H.
dc.contributor.author Chesi, A.
dc.contributor.author Choi, S.H.
dc.contributor.author Chung, R.H.
dc.contributor.author Cocca, M.
dc.contributor.author Concas, M.P.
dc.contributor.author Couture, C.
dc.contributor.author Cuellar-Partida, G.
dc.contributor.author Danning, R.
dc.contributor.author Daw, E.W.
dc.contributor.author Degenhard, F.
dc.contributor.author Delgado, G.E.
dc.contributor.author Delitala, A.
dc.contributor.author Demirkan, A.
dc.contributor.author Deng, X.
dc.contributor.author Devineni, P.
dc.contributor.author Dietl, A.
dc.contributor.author Dimitriou, M.
dc.contributor.author Dimitrov, L.
dc.contributor.author Dorajoo, R.
dc.contributor.author Ekici, A.B.
dc.contributor.author Engmann, J.E.
dc.contributor.author Fairhurst-Hunter, Z.
dc.contributor.author Farmaki, A.E.
dc.contributor.author Faul, J.D.
dc.contributor.author Fernandez-Lopez, J.C.
dc.contributor.author Forer, L.
dc.contributor.author Francescatto, M.
dc.contributor.author Freitag-Wolf, S.
dc.contributor.author Fuchsberger, C.
dc.contributor.author Galesloot, T.E.
dc.contributor.author Gao, Y.
dc.contributor.author Gao, Z.
dc.contributor.author Geller, F.
dc.contributor.author Giannakopoulou, O.
dc.contributor.author Giulianini,F.
dc.contributor.author Gjesing, A.P.
dc.contributor.author Goel, A.
dc.contributor.author Gordon, S.D.
dc.contributor.author Gorski, M.
dc.contributor.author Grove, J.
dc.contributor.author Guo, X.
dc.contributor.author Gustafsson, S.
dc.contributor.author Haessler, J.
dc.contributor.author Hansen, T.F.
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dc.contributor.author Hebbar, P.
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dc.contributor.author Hung, Y.J.
dc.contributor.author Huo, S.
dc.contributor.author Hwang, M.Y.
dc.contributor.author Ha, H.
dc.contributor.author Ikeda, D.D.
dc.contributor.author Isono, M.
dc.contributor.author Jackson, A.U.
dc.contributor.author Jäger, S.
dc.contributor.author Jansen, I.E.
dc.contributor.author Johansson, I.
dc.contributor.author Jonas, J.B.
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dc.contributor.author Jørgensen, T.
dc.contributor.author Kalafati, I.P.
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dc.contributor.author Kanoni, S.
dc.contributor.author Kårhus, L.L.
dc.contributor.author Kasturiratne, A.
dc.contributor.author Katsuya, T.
dc.contributor.author Kawaguchi, T.
dc.contributor.author Kember, R.L.
dc.contributor.author Kentistou, K.A.
dc.contributor.author Kim, H.N.
dc.contributor.author Kim, Y.J.
dc.contributor.author Kleber, M.E.
dc.contributor.author Knol, M.J.
dc.contributor.author Kurbasic, A.
dc.contributor.author Lauzon, M.
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dc.contributor.author Lea, R.
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dc.contributor.author Mahajan, A.
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dc.contributor.author Mavarani, L.
dc.contributor.author McDaid, A.F.
dc.contributor.author Meidtner, K.
dc.contributor.author Melendez, T.L.
dc.contributor.author Mercader, J.M.
dc.contributor.author Milaneschi, Y.
dc.contributor.author Miller, J.E.
dc.contributor.author Millwood, I.Y.
dc.contributor.author Mishra, P.P.
dc.contributor.author Mitchell, R.E.
dc.contributor.author Møllehave, L.T.
dc.contributor.author Morgan, A.
dc.contributor.author Mucha, S.
dc.contributor.author Munz, M.
dc.contributor.author Nakatochi, M.
dc.contributor.author Nelson, C.P.
dc.contributor.author Nethander, M.
dc.contributor.author Nho, C.W.
dc.contributor.author Nielsen, A.A.
dc.contributor.author Nolte, I.M.
dc.contributor.author Nongmaithem, S.S.
dc.contributor.author Noordam, R.
dc.contributor.author Ntalla, I.
dc.contributor.author Nutile, T.
dc.contributor.author Pandit, A.
dc.contributor.author Christofidou, P.
dc.contributor.author Pärna, K.
dc.contributor.author Pauper, M.
dc.contributor.author Petersen, E.R.B.
dc.contributor.author Petersen, L.V.
dc.contributor.author Pitkänen, N.
dc.contributor.author Polašek, O.
dc.contributor.author Poveda, A.
dc.contributor.author Preuss, M.H.
dc.contributor.author Pyarajan, S.
dc.contributor.author Raffield, L.M.
dc.contributor.author Rakugi, H.
dc.contributor.author Ramirez, J.
dc.contributor.author Rasheed, A.
dc.contributor.author Raven, D.
dc.contributor.author Rayner, N.W.
dc.contributor.author Riveros, C.
dc.contributor.author Rohde, R.
dc.contributor.author Ruggiero, D.
dc.contributor.author Ruotsalainen, S.E.
dc.contributor.author Ryan, K.A.
dc.contributor.author Sabater-Lleal, M.
dc.contributor.author Saxena, R.
dc.contributor.author Scholz, M.
dc.contributor.author Sendamarai, A.
dc.contributor.author Shen, B.
dc.contributor.author Shi, J.
dc.contributor.author Shin, J.H.
dc.contributor.author Sidore, C.
dc.contributor.author Sitlani, C.M.
dc.contributor.author Slieker, R.C.
dc.contributor.author Smit, R.A.J.
dc.contributor.author Smith, A.V.
dc.contributor.author Smith, J.A.
dc.contributor.author Smyth, L.J.
dc.contributor.author Southam, L.
dc.contributor.author Steinthorsdottir, V.
dc.contributor.author Sun, L.
dc.contributor.author Takeuchi, F.
dc.contributor.author Tallapragada, D.S.P.
dc.contributor.author Taylor, K.D.
dc.contributor.author Tayo, B.O.
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dc.contributor.author Terzikhan, N.
dc.contributor.author Tesolin, P.
dc.contributor.author Teumer, A.
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dc.contributor.author Thompson, D.J.
dc.contributor.author Thorleifsson, G.
dc.contributor.author Timmers, P.R.H.J.
dc.contributor.author Trompet, S.
dc.contributor.author Turman, C.
dc.contributor.author Vaccargiu, S.
dc.contributor.author van der Laan, S.W.
dc.contributor.author van der Most, P.J.
dc.contributor.author van Klinken, J.B.
dc.contributor.author van Setten, J.
dc.contributor.author Verma, S.S.
dc.contributor.author Verweij, N.
dc.contributor.author Veturi, Y.
dc.contributor.author Wang, C.A.
dc.contributor.author Wang, C.
dc.contributor.author Wang, L.
dc.contributor.author Wang, Z.
dc.contributor.author Warren, H.R.
dc.contributor.author Bin Wei, W.
dc.contributor.author Wickremasinghe, A.R.
dc.contributor.author Wielscher, M.
dc.contributor.author Wiggins, K.L.
dc.contributor.author Winsvold, B.S.
dc.contributor.author Wong, A.
dc.contributor.author Wu, Y.
dc.contributor.author Wuttke, M.
dc.contributor.author Xia, R.
dc.contributor.author Xie, T.
dc.contributor.author Yamamoto, K.
dc.contributor.author Yang, J.
dc.contributor.author Yao, J.
dc.contributor.author Young, H.
dc.contributor.author Yousri, N.A.
dc.contributor.author Yu, L.
dc.contributor.author Zeng, L.
dc.contributor.author Zhang, W.
dc.contributor.author Zhang, X.
dc.contributor.author Zhao, J.H.
dc.contributor.author Zhao. W.
dc.contributor.author Zhou, W.
dc.contributor.author Zimmermann, M.E.
dc.contributor.author Zoledziewska, M.
dc.contributor.author Adair, L.S.
dc.contributor.author Adams, H.H.H.
dc.contributor.author Aguilar-Salinas, C.A.
dc.contributor.author Al-Mulla, F.
dc.contributor.author Arnett, D.K.
dc.contributor.author Arnett, D.K.
dc.contributor.author Asselbergs, F.W.
dc.contributor.author Åsvold, B.O.
dc.contributor.author Attia, J.
dc.contributor.author Banas, B.
dc.contributor.author Bandinelli, S.
dc.contributor.author Bennett D.A.
dc.contributor.author Bergler, T.
dc.contributor.author Bharadwaj, D.
dc.contributor.author Biino, G.
dc.contributor.author Bisgaard, H.
dc.contributor.author Boerwinkle, E.
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dc.contributor.author Tusié-Luna, M.T.
dc.contributor.author Uitterlinden, A.G.
dc.contributor.author van Dam, R.M.
dc.contributor.author van der Harst, P.
dc.contributor.author Van der Velde, N.
dc.contributor.author van Duijn, C.M.
dc.contributor.author van Schoor, N.M.
dc.contributor.author Vitart, V.
dc.contributor.author Völker, U.
dc.contributor.author Vollenweider, P.
dc.contributor.author Völzke, H.
dc.contributor.author Wacher-Rodarte, N.H.
dc.contributor.author Walker, M.
dc.contributor.author Wang, Y.X.
dc.contributor.author Wareham, N.J.
dc.contributor.author Watanabe, R.M.
dc.contributor.author Watkins, H.
dc.contributor.author Weir, D.R.
dc.contributor.author Werge, T.M.
dc.contributor.author Widen, E.
dc.contributor.author Wilkens, L.R.
dc.contributor.author Willemsen, G.
dc.contributor.author Willett, W.C.
dc.contributor.author Wilson, J.F.
dc.contributor.author Wong, T.Y.
dc.contributor.author Woo, J.T.
dc.contributor.author Wright, A.F.
dc.contributor.author Wu, J.Y.
dc.contributor.author Xu, H.
dc.contributor.author Yajnik, C.S.
dc.contributor.author Yokota, M.
dc.contributor.author Yuan, J.M.
dc.contributor.author Zeggini, E.
dc.contributor.author Zemel, B.S.
dc.contributor.author Zheng, W.
dc.contributor.author Zhu, X.
dc.contributor.author Zmuda, J.M.
dc.contributor.author Zonderman, A.B.
dc.contributor.author Zwart, J.A.
dc.contributor.author 23andMe Research Team
dc.contributor.author VA Million Veteran Program.
dc.contributor.author DiscovEHR (DiscovEHR and MyCode Community Health Initiative).
dc.contributor.author eMERGE (Electronic Medical Records and Genomics Network).
dc.contributor.author Lifelines Cohort Study.
dc.contributor.author PRACTICAL Consortium.
dc.contributor.author Understanding Society Scientific Group.
dc.contributor.author Chasman, D.I.
dc.contributor.author Cho, Y.S.
dc.contributor.author Heid, I.M.
dc.contributor.author McCarthy, M.I.
dc.contributor.author Ng, M.C.Y.
dc.contributor.author O'Donnell, C.J.
dc.contributor.author Rivadeneira, F.
dc.contributor.author Thorsteinsdottir, U.
dc.contributor.author Sun, Y.V.
dc.contributor.author Tai, E.S.
dc.contributor.author Boehnke, M.
dc.contributor.author Deloukas, P.
dc.contributor.author Justice, A.E.
dc.contributor.author Lindgren, C.M.
dc.contributor.author Loos, R.J.F.
dc.contributor.author Mohlke, K.L.
dc.contributor.author North, K.E.
dc.contributor.author Stefansson, K.
dc.contributor.author Walters R.G.v.
dc.contributor.author Winkler, T.W.
dc.contributor.author Young, K.L.
dc.contributor.author Loh, P.R.
dc.contributor.author Yang, J.
dc.contributor.author Esko, T.
dc.contributor.author Assimes, T.L.
dc.contributor.author Auton, A.
dc.contributor.author Abecasis, G.R.
dc.contributor.author Willer, C.J.
dc.contributor.author Locke, A.E.
dc.contributor.author Berndt, S.I.
dc.contributor.author Lettre, G.
dc.contributor.author Frayling, T.M.
dc.contributor.author Frayling, T.M.
dc.contributor.author Okada, Y.
dc.contributor.author Wood, A.R.
dc.contributor.author Visscher, P.M.
dc.contributor.author Hirschhorn, J.N.
dc.date.accessioned 2022-11-17T05:11:41Z
dc.date.available 2022-11-17T05:11:41Z
dc.date.issued 2022
dc.identifier.citation Nature.2022;610(7933):704-712. en_US
dc.identifier.issn 0028-0836
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/25593
dc.description indexed in MEDLINE. en_US
dc.description.abstract Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel2) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10-20% (14-24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries. en_US
dc.language.iso en en_US
dc.publisher Nature Publishing Group en_US
dc.subject Common genetic en_US
dc.title A saturated map of common genetic variants associated with human height en_US
dc.type Article en_US


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