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Antenatal oral glucose tolerance test abnormalities in the prediction of future risk of postpartum diabetes in women with gestational diabetes: Results from the living study

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dc.contributor.author Gupta, Y.
dc.contributor.author Kapoor, D.
dc.contributor.author Lakshmi, J.K.
dc.contributor.author Praveen, D.
dc.contributor.author Santos, J.A.
dc.contributor.author Billot, L.
dc.contributor.author Naheed, A.
dc.contributor.author De Silva, H.A.
dc.contributor.author Gupta, I.
dc.contributor.author Farzana, N.
dc.contributor.author John, R.
dc.contributor.author Ajanthan, S.
dc.contributor.author Bhatla, N.
dc.contributor.author Desai, A.
dc.contributor.author Pathmeswaran, A.
dc.contributor.author Prabhakaran, D.
dc.contributor.author Teede, H.
dc.contributor.author Zoungas, S.
dc.contributor.author Patel, A.
dc.contributor.author Tandon, N.
dc.date.accessioned 2024-07-24T06:40:43Z
dc.date.available 2024-07-24T06:40:43Z
dc.date.issued 2024
dc.identifier.citation Journal of Diabetes.2024;16(5):e13559. en_US
dc.identifier.issn 1753-0393 (Print)
dc.identifier.issn 1753-0407 (Electronic)
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/27919
dc.description Indexed in MEDLINE. en_US
dc.description.abstract OBJECTIVES To explore associations between type and number of abnormal glucose values on antenatal oral glucose tolerance test (OGTT) with postpartum diabetes in South Asian women diagnosed with gestational diabetes (GDM) using International Association of the Diabetes and Pregnancy Study Groups criteria.METHODS This post-hoc evaluation of the Lifestyle Intervention IN Gestational Diabetes (LIVING) study, a randomized controlled trial, was conducted among women with GDM in the index pregnancy, across 19 centers in Bangladesh, India, and Sri Lanka. Postpartum diabetes (outcome) was defined on OGTT, using American Diabetes Association (ADA) criteria.RESULTS We report data on 1468 women with GDM, aged 30.9 (5.0) years, and with median (interquartile range) follow-up period of 1.8 (1.4-2.4) years after childbirth following the index pregnancy. We found diabetes in 213 (14.5%) women with an incidence of 8.7 (7.6-10.0)/100 women-years. The lowest incidence rate was 3.8/100 women years, in those with an isolated fasting plasma glucose (FPG) abnormality, and highest was 19.0/100 women years in participants with three abnormal values. The adjusted hazard ratios for two and three abnormal values compared to one abnormal value were 1.73 (95% confidence interval [CI], 1.18-2.54; p = .005) and 3.56 (95% CI, 2.46-5.16; p < .001) respectively. The adjusted hazard ratio for the combined (combination of fasting and postglucose load) abnormalities was 2.61 (95% CI, 1.70-4.00; p < .001), compared to isolated abnormal FPG.CONCLUSIONS Risk of diabetes varied significantly depending upon the type and number of abnormal values on antenatal OGTT. These data may inform future precision medicine approaches such as risk prediction models in identifying women at higher risk and may guide future targeted interventions. en_US
dc.language.iso en en_US
dc.publisher Blackwell Publishing Asia en_US
dc.subject South Asia en_US
dc.subject Antenatal OGTT en_US
dc.subject Gestational diabetes mellitus en_US
dc.subject Postpartum en_US
dc.subject Risk prediction en_US
dc.subject Type 2 diabetes mellitus en_US
dc.title Antenatal oral glucose tolerance test abnormalities in the prediction of future risk of postpartum diabetes in women with gestational diabetes: Results from the living study en_US
dc.type Article en_US


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