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Diffuse and nodular type hepatoma: a prospective, comparative study

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dc.contributor.author Wickramarathne, S.D.J. en_US
dc.contributor.author Jayarathne, V.S. en_US
dc.contributor.author Siriwardana, R.C. en_US
dc.contributor.author Niriella, M.A. en_US
dc.contributor.author Liyanage, C.A.H. en_US
dc.contributor.author Dassanayake, A.S. en_US
dc.contributor.author Gunetilleke, M.B. en_US
dc.contributor.author de Silva, H.J. en_US
dc.date.accessioned 2015-09-21T06:52:40Z en_US
dc.date.available 2015-09-21T06:52:40Z
dc.date.issued 2014 en_US
dc.identifier.citation The Ceylon Medical Journal. 2014; 59(Supplement 1):86-87 en_US
dc.identifier.issn 0009-0875 (Print)
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/9714 en_US
dc.description Poster Presentation Abstract (PP82), 127th Annual Scientific Sessions, Sri Lanka Medical Association, 2014 Colombo, Sri Lanka en_US
dc.description.abstract INTRODUCTIONS: Incidence of hepatocellular carcinoma (HCC) is increasing. Diffuse type HCC is rare and data on such tumors are limited. METHODS: All patients referred to North Colombo Liver Unit with HCC from September 2011 to February 2014 were included. Data were collected prespectively from 206 patients. Tumors with diffuse margin in imaging were categorized as diffuse HCC (n-41, 21%). Baseline parameters, treatment options and survival were compared with nodulartype'HCC. RESULTS: 87.8% of patients in the diffuse HCC group were males compared to 89.54 % in nodular HCC group. The median age in the two groups were similar (nodular 62.13 years (range 12-88), diffuse 63.58 years (range 47-76)). Heavy alcohol use was commoner in the diffuse HCC group (68.9% vs. 41.7 %, p=0.002). 90.2% with diffuse HCC had cirrhosis compared to 79.1% with nodular HCC (p<0.05). Aspartate transaminase (AST), alanine transarninase (ALT), INR, total bilirubin, platelet count, MELD score were similar in two groups. Alfa Feto Protein (AFP) value was significantly higher in diffuse HCC group (p<0.001). 80.5% patients with diffuse type HCC had typical enhancement pattern compared to 84.4% with nodular type. Diffuse HCC group had higher incidence of major vascular invasion (78% vs. 23.5%, p<0.001). 76.9% of diffuse HCC group had only palliative care compared to 28.4% in nodular type (p<0.001). Median survival in diffuse group was 2.0 months compared to 8.0 months in nodular type. CONCLUSIONS: 21% of HCC are diffuse type. Alcohol intake was commoner in this group. Diffuse HCC had poorer prognosis with high AFP level and vascular invasion. Majority had advanced disease at presentation. en_US
dc.language.iso en_US en_US
dc.publisher Sri Lanka Medical Association en_US
dc.subject hepatoma en_US
dc.title Diffuse and nodular type hepatoma: a prospective, comparative study en_US
dc.type Conference Abstract en_US


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